Over the last few decades problems related to microplastic has gained even more interest, fast becoming a topic that has generated an increasing international big concern related to the health of the marine life and human welfare. Every ocean, sea and waterway are affected by this source of contamination and the Mediterranean Sea is not an exception as it represents one of the more impacted seas. Recent investigations have revealed that different compartments of marine life are interested in microplastic contamination and, as the Aegean Sea is one of the most important marine biodiversity hotspots in the Mediterranean, it is crucial to preserve the integrity of this ecosystem by studying the impact that microplastics have caused. In our laboratories we investigate the abundance of microplastics from different sources including water, sediment, Posidonia oceanica seagrass, sea urchins and wild and farmed fish to infer information about the potential spatial distribution and biomagnification in the trophic net.